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Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease - A Focus on Early Phase Clinical Drug Development (Hardcover, 2nd ed. 2019)
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Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease - A Focus on Early Phase Clinical Drug Development (Hardcover, 2nd ed. 2019)
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This book aims to aid the selection of the most appropriate methods
for use in early phase (1 and 2) clinical studies of new drugs for
diabetes, obesity, non-alcoholic fatty liver disease (NAFLD) and
related cardiometabolic disorders. Clinical research methods to
assess the pharmacokinetics and pharmacodynamics of new diabetes
drugs, e.g. the euglycemic clamp technique, have become
well-established in proof-of-mechanism studies. However, selection
of the most appropriate techniques is by no means straightforward.
Moreover, the application of such methods must conform to the
regulatory requirements for new drugs. This book discusses the need
for new pharmacotherapies for diabetes, obesity and NAFLD and the
molecular targets of drugs currently in development. Emerging
technologies including functional imaging, circulating biomarkers
and omics are considered together with practical and ethical issues
pertaining to early phase clinical trials in subjects with
cardiometabolic disorders. Translational Research Methods in
Diabetes, Obesity, and Non-Alcoholic Fatty Liver Disease is of
interest to biomedical scientists, pharmacologists, academics
involved in metabolic research and clinicians practicing in these
specialties.
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