"Autologous Stem Cell Transplantation" integrates basic research
and clinical aspects underlying the most recent results in those
malignant diseases where progress is most effective.
Recent evidence shows that higher doses are better in inducing
higher cure rates in hematological neoplasias, although
myeloblation related to dose intensity can be a limiting factor.
The toxicity can now be controlled with autologous marrow and
peripheral blood progenitor cell transplantation, used with or
without growth factors. The combination of high dose
chemoradiotherapy followed by re-infusion of autologous stem cells
constitute a dramatic advance in the treatment of refactory and
relapse hematological neoplasias.
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