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Books > Science & Mathematics > Biology, life sciences > Biochemistry > Proteins
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Protein Deimination in Human Health and Disease (Hardcover, 2nd ed. 2017)
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Protein Deimination in Human Health and Disease (Hardcover, 2nd ed. 2017)
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Published in 2014, Protein Deimination in Human Health and Disease
was the first book on this novel post-translational modification,
in which selected positively-charged arginine amino acids are
converted to neutral citrulline amino acids by the
peptidyl-arginine deiminase (PAD) family of enzymes. This area of
research continues to expand rapidly, necessitating the need for
this second edition. Chronicling the latest inflammatory,
epigenetic, neurodegenerative, and carcinogenic processes, Protein
Deimination in Human Health and Disease, Second Edition, updates
the latest advances in deimination research, including new
information on PAD enzyme structure and activity, and how PAD
knock-out animals are being used to study known and
newly-discovered links to various human diseases. The first edition
outlined what was known about citrullinated proteins in normal
tissues such as skin and hair, as well as in maladies such as
rheumatoid arthritis (RA), multiple sclerosis (MS), Alzheimer's
disease (AD), glaucoma, peripheral nerve injury, neonatal hypoxic
brain damage, and breast cancer. This second edition addresses
numerous additional disorders such as diabetes, asthma, traumatic
brain injury, inflammatory bowel disease, lupus, bone disease,
heart failure, fronto-temporal dementia, and prostate and colon
cancer. It also provides updates on the deimination research
covering the three seminal diseases first linked to this process
(RA, MS and AD), and details how auto-antibodies against
citrullinated proteins contribute to disease. In addition, new
hypotheses on the possible pathologic mechanisms of citrullinated
myelin basic protein and glial fibrillary acidic protein are also
proposed. This second edition also outlines the latest developments
in therapeutic strategies, including the use of new PAD antagonists
and innovative techniques such as micro-vescicles and stem cells as
possible mechanisms to treat these conditions.
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