This book offers comprehensive information on the polymorphisms of
genes encoding pattern recognition receptors (PRRs). Following a
short description of the general role of PRRs in the immune system,
the structure and function of Toll-like and NOD-like receptors are
examined in detail. The main focus is on the role of inherited
variation in PRRs and their correlation to cancer and
cardiovascular diseases. A review of all epidemiological
investigations is included, and a concept of genomic risk markers
for the prevention of various diseases is also discussed.
General
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