This series encompasses design, synthesis, application, and
analytical methods (including clinical and in vitro) for the study
of these critical interactions. As our understanding of the genome
and proteome expands, general developments in the field of DNA
sequence specific interaction are likely to play an increasingly
important role. Accordingly, manuscripts have been solicited from
experts covering a diverse range of fields, reflecting the
cross-disciplinary and dynamic nature of the series.
Volume 4 describes work on the modification of DNA by AT specific
anticancer drugs, DNA alkylation events which involve metabolite
generation, DNA sequence recognition by two selective binders,
bulged DNA microenvironments as molecular targets, DNA sequence
specific binding by short peptides and the analysis of DNA-protein
interactions using DNase I footprinting methodology.
Features include:
Expert contributors from the Biomedical world
Emerging areas of drug design and therapeutic applications
Nucleic acid-protein interactions
Color graphics of molecular modeling analyses
New and emerging methodologies
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General
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