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Aquaporins (Hardcover, 1st ed. 2017)
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Aquaporins (Hardcover, 1st ed. 2017)
Series: Advances in Experimental Medicine and Biology, 969
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This book provides a state-of-the-art report on our current
understanding of aquaporins and the future direction of the field.
Aquaporins (AQPs) are a group of water-channel proteins that are
specifically permeable to water and other small molecules, such as
glycerol and urea. To date thirteen water-channel proteins (AQP0 -
AQP12) have been cloned and the mechanisms and physiological
functions of water transport across biological membranes have long
been the subject of interest. Recent advances in the molecular
biology and physiology of water transport have yielded new insights
into how and why water moves across cell membranes, and studies on
aquaporin knockout mouse models suggest that aquaporins are
involved in the development of some diseases and they may be useful
targets of research into selective-inhibitor drugs. By focusing on
the advances made over the last 20 years in the biophysics,
genetics, protein structure, molecular biology, physiology,
pathophysiology and pharmacology of aquaporins in mammalian cell
membranes, this book provides novel insights into further
mechanisms and the physiological significance of water and some
small molecule transport in mammals in order to stimulate further
research in new directions.
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