Resistance of Cancer Cells to CTL-Mediated Immunotherapy (Hardcover, 2015 ed.)

This comprehensive volume explores the latest research on the mechanisms of resistance in cancer cells to CTL-mediated immunotherapy. Chapter topics discuss cell-mediated immunity as the result of cytotoxic T-lymphocytes (CTL) directed specifically against cancer cells. In addition, the volume reviews how CTL mediate the cytotoxic activity, in large part, by the indication of apoptosis; hence, tumor cells develop anti-apoptotic mechanisms and thereby, resist CTL-induced apoptosis. In order for CTL-mediated antitumor immunotherapy to be effective, it is essential that agents directed against the resistant tumor cells sensitized cancer cells for CTL-mediated apoptosis. Examples of such agents discussed in the volume include are HDAC inhibitors, proteasome inhibitors, Bcl-2 family inhibitors, PARP, antibodies, and more.

General

Imprint:	Springer International Publishing AG
Country of origin:	Switzerland
Series:	Resistance to Targeted Anti-Cancer Therapeutics, 7
Release date:	June 2015
First published:	2015
Editors:	Benjamin Bonavida • Salem Chouaib
Dimensions:	235 x 155 x 21mm (L x W x T)
Format:	Hardcover
Pages:	353
Edition:	2015 ed.
ISBN-13:	978-3-319-17806-6
Categories:	Books > Medicine > General issues > Medical equipment & techniques > Medical research Books > Medicine > Other branches of medicine > Pharmacology > General Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General
LSN:	3-319-17806-7
Barcode:	9783319178066

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