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Specificity and Function of Clonally Developing T Cells (Paperback, Softcover reprint of the original 1st ed. 1986)
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Specificity and Function of Clonally Developing T Cells (Paperback, Softcover reprint of the original 1st ed. 1986)
Series: Current Topics in Microbiology and Immunology, 126
Expected to ship within 10 - 15 working days
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The international workshop on "Specificity and Function of Clonally
Developing T Cells" was held at SchloG Rei- sensburg (near UIm,
West Germany) on March 17-20, 1985. The meeting brought together
immunologists study- ing clonal T-cell development in man and mouse
in various in vitro systems at the cellular as well as molecular
level. It was an attempt to provide an overview of the current
research interests of groups working on (a) the developmen- tal
potential of in vitro expanding primary T-cell clones (investigated
using limiting dilution analysis) and cloned T -cell lines
established in long-term culture; (b) the signals required for the
expression of particular patterns of (func- tional and antigen
receptor) phenotypes by T cells which are either freshly explanted
in vitro, or maintained in vitro as cloned long-term lines; and (c)
the generation of an MHC-restricted T-cell repertoire. In the study
of thymocytes emphasis has shifted towards the presumably immature
adult/embryonic subset(s) which is (are) devoid of subset-specific
differentiation markers (L3T4, Lyt-2). Neither the signal
requirement(s) for clonal expansion in vitro of these cells, nor
their precursor role for any functional T -cell lineage are as yet
unambiguously established. The multiple modes of human T-cell
activation (e.g., via Tp44, T11, T3/Ti molecular complexes) were
em- phasized by a number of presentations and raised the ques- tion
of whether these different modes of activation induce different
functional activities in individual T-cell clones.
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