Cancer Drug Resistance (Hardcover, 2006 ed.)

Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.

General

Imprint:	HumanaPress
Country of origin:	United States
Series:	Cancer Drug Discovery and Development
Release date:	March 2006
First published:	2006
Editors:	Beverly A. Teicher
Dimensions:	254 x 178 x 28mm (L x W x T)
Format:	Hardcover
Pages:	617
Edition:	2006 ed.
ISBN-13:	978-1-58829-530-9
Categories:	Books > Medicine > Nursing & ancillary services > Specific disorders & therapies > Addiction & therapy Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General
LSN:	1-58829-530-3
Barcode:	9781588295309

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