An authoritative collection of optimal techniques for producing and
characterizing the immunologically active cells and effector
molecules now gaining wide use in the clinical treatment of
patients. Taking advantage of the latest technologies, the authors
present readily reproducible experimental protocols for the study
of dendritic cells, T cells, monoclonal antibodies, and bone marrow
transplantation. The emphasis is on preclinicical and clinical
applications and on the progress of selected approaches in clinical
trials. Additional chapters cover the molecular definition of
target antigens, mathematical modeling approaches to immunotherapy,
and the utilization of regulatory T cells. The protocols make it
possible to study the adoptive transfer of tailored
antigen-specific immune cells and to improve the clinical
application of adoptive immunotherapy.
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