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Amyloid Protein Precursor in Development, Aging and Alzheimer's Disease (Paperback, Softcover reprint of the original 1st ed. 1994)
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Amyloid Protein Precursor in Development, Aging and Alzheimer's Disease (Paperback, Softcover reprint of the original 1st ed. 1994)
Series: Research and Perspectives in Alzheimer's Disease
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This volume contains the proceedings of the ninth "Colloque
medecine et recherche" of the Fondation IPSEN devoted to research
on Alzheimer's disease. This symposium was held in Lyon on June 21,
1993, on the topic, "Amyloid Protein Precursors in Development,
Aging and Alzheimer's Disease". The choice of this venue and of
this particular subject was not a matter of chance. As far as the
history of medicine and neurology is concerned, Lyon is doubtless
one of the most famous cities in France and the F ondation IPSEN
had to organize one of its meetings in this city which has been
regarded for centuries as a major crossroads. Regarding the topic,
the amyloid story is at the center of the debate in the field of
Alzheimer's studies. For nearly 10 years, "alzheimerology" has more
or less been intertwined with "amyloidology". The purification and
the sequencing of the beta/ A4 peptide in amyloid congophilic
angiopathy (Glenner and Wong 1984) and in Alzheimer's disease
(Masters et al. 1985) were the first steps toward the numerous
successes realised in the last few years. The discovery of the
amyloid precursor protein (APP), the localisation of its gene on
chromosome 21 and the sequencing of its cDNA in 1987 (Kang et al.
1987; Goldgaber et al. 1987; Robakis et al.
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