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Radioimmunoassay in Basic and Clinical Pharmacology (Paperback, Softcover reprint of the original 1st ed. 1987)
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Radioimmunoassay in Basic and Clinical Pharmacology (Paperback, Softcover reprint of the original 1st ed. 1987)
Series: Handbook of Experimental Pharmacology, 82
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Thirty years have elapsed since the first description by S. A.
BERSON and R. S. Y ALOW of the basic principles of radioimmunoassay
(RIA). During this period of time, RIA methodology has been
instrumental to the growth of many areas of biomedical research,
including endocrinology, oncology, hematology, and pharmacology. It
has done so by providing a relatively simple universal tool
allowing, for the first time, the detection of endogenous mediators
that are present 12 10 in body fluids at concentrations as low as
10- _10- M. The fundamental nature of this discovery and the
wide-ranging fall-out of basic and clinical knowledge derived from
its application have been acknowledged by the many honors tributed
to its pioneers, including the Nobel Prize awarded to Dr. Y ALOW 10
years ago. Although several excellent books have been published
during the past decades covering various aspects of RIA
methodology, we felt the need, as pharmacologists, for a
comprehensive discussion of the methodological and conceptual
issues related to the main classes of mediators of drug action and
to drugs themselves. Thus, we gladly accepted the challenge
provided by the invitation to edit a volume of the Handbook of
Experimental Pharmacology on Radioimmunoassay in Basic and Clinical
Pharmacology. We tried to balance the emphasis placed on more
general aspects of the RIA methodology and that on specific
mediators.
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