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Books > Medicine > Pre-clinical medicine: basic sciences > Medical genetics
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Human Epigenetics: How Science Works (Paperback, 1st ed. 2019)
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Human Epigenetics: How Science Works (Paperback, 1st ed. 2019)
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The view "It's all in our genes and we cannot change it" developed
in the past 150 years since Gregor Mendel's experiments with
flowering pea plants. However, there is a special form of genetics,
referred to as epigenetics, which does not involve any change of
our genes but regulates how and when they are used. In the cell
nucleus our genes are packed into chromatin, which is a complex of
histone proteins and genomic DNA, representing the molecular basis
of epigenetics. Our environment and lifestyle decisions influence
the epigenetics of our cells and organs, i.e. epigenetics changes
dynamically throughout our whole life. Thus, we have the chance to
change our epigenetics in a positive as well as negative way and
present the onset of diseases, such a type 2 diabetes or cancer.
This textbook provides a molecular explanation how our genome is
connected with environmental signals. It outlines that epigenetic
programming is a learning process that results in epigenetic memory
in each of the cells of our body. The central importance of
epigenetics during embryogenesis and cellular differentiation as
well as in the process of aging and the risk for the development of
cancer are discussed. Moreover, the role of the epigenome as a
molecular storage of cellular events not only in the brain but also
in metabolic organs and in the immune system is described. The book
represents an updated but simplified version of our textbook "Human
Epigenomics" (ISBN 978-981-10-7614-8). The first five chapters
explain the molecular basis of epigenetics, while the following
seven chapters provide examples for the impact of epigenetics in
human health and disease.
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