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Books > Medicine > Clinical & internal medicine > Haematology
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Iron Chelation Therapy (Paperback, Softcover reprint of the original 1st ed. 2002)
Loot Price: R2,465
Discovery Miles 24 650
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Iron Chelation Therapy (Paperback, Softcover reprint of the original 1st ed. 2002)
Series: Advances in Experimental Medicine and Biology, 509
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Within the last few years, iron research has yielded exciting new
insights into the under standing of normal iron homeostasis.
However, normal iron physiology offers little protec tion from the
toxic effects of pathological iron accumulation, because nature did
not equip us with effective mechanisms of iron excretion. Excess
iron may be effectively removed by phlebotomy in hereditary
hemochromatosis, but this method cannot be applied to chronic
anemias associated with iron overload. In these diseases, iron
chelating therapy is the only method available for preventing early
death caused mainly by myocardial and hepatic iron toxicity. Iron
chelating therapy has changed the quality of life and life
expectancy of thalassemic patients. However, the high cost and
rigorous requirements of deferoxamine therapy, and the significant
toxicity of deferiprone underline the need for the continued
development of new and improved orally effective iron chelators.
Such development, and the evolution of improved strategies of iron
chelating therapy require better understanding of the
pathophysiology of iron toxicity and the mechanism of action of
iron chelating drugs. The timeliness of the present volume is
underlined by several significant develop ments in recent years.
New insights have been gained into the molecular basis of aberrant
iron handling in hereditary disorders and the pathophysiology of
iron overload (Chapters 1-5)."
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