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The Identities of Membrane Steroid Receptors - ...And Other Proteins Mediating Nongenomic Steroid Action (Paperback, Softcover reprint of the original 1st ed. 2003)
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The Identities of Membrane Steroid Receptors - ...And Other Proteins Mediating Nongenomic Steroid Action (Paperback, Softcover reprint of the original 1st ed. 2003)
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Cheryl S. Watson University o/Texas Medical Branch Cellular steroid
action has been thoroughly studied in the nuclear compartment.
However, nuclear steroid receptor mechanisms have been unable to
explain some of the rapid activities of steroids, partiCUlarly
those which occur in a time frame of seconds to minutes [reviewed
in (1;2)]. Based on these and other considerations, an alternative
membrane-associated receptor form was long ago proposed to exist
(3). Others interpret the location of the steroid receptors
mediating these rapid effects as peri membrane or cytoplasmic. New
experimental tools have been brought to bear on the topic of
receptors for steroids which mediate non-genomic actions, and thus
investigative activity and focus regarding this type of steroid
receptor has recently increased significantly. However, there may
be multiple answers to the question "how do steroids mediate rapid
nongenomic effects?" Steroid actions initiated at the cell membrane
can impinge on important phases in the lifespan of a cell:
proliferation, migration, differentiation, and release of hormones
or neurotransmitters functioning as signals to other cells.
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