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Cortical Development - From Specification to Differentiation (Paperback, Softcover reprint of the original 1st ed. 2002)
Loot Price: R4,429
Discovery Miles 44 290
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Cortical Development - From Specification to Differentiation (Paperback, Softcover reprint of the original 1st ed. 2002)
Series: Results and Problems in Cell Differentiation, 39
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Total price: R4,449
Discovery Miles: 44 490
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The cerebral neo cortex, unique to mammals, is regarded as the
prerequisite for higher cognitive function and is the structure
most closely associated with the idea of the "mind" . Expansion of
mental capa city between mammals is most typically associated with
an evolutionary increase in neocortical volume that culminates in
the intricately folded configuration of sulci and gyri so charac
teristic of the primate cerebral cortex. Yet, the basic unit
structure and funda mental connectivity of cortex appears to have
been preserved from the smooth cortex of the mouse or rat to the
highly convoluted cortical mantle of the human that, if stretched
out as a sheet, would be large enough to wrap the entire human
brain multiple times. The basic similarity in structure and func
tion has made it possible to conduct studies in the relatively
simple cortices of rat or mouse and have the results pertain to the
understanding of the primate, including human, cortex. The neo
cortex is an intriguing structure for the study of cell
differentiation. Its dozens of neuronal cell types and small
handful of different glial types have their origin in a
pseudostratified germinal epithelium lining the ventricular surface
of the forebrain. In its mature form, neocortex is a six-Iayered
struc ture; five of its layers contain multiple different but
characteristic neuronal types with the sixth occupied by neuronal
processes. Various glial cells are dis persed throughout all six
layers.
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