Free-Radical-Induced DNA Damage and Its Repair - A Chemical Perspective (Hardcover, 2006 ed.)

Understanding of the molecular basis of DNA damage and its repair has increased dramatically in recent years and there is now a substantial knowledge concerning the products that arise from free-radical attack on DNA. Free-radical DNA damage may lead to mutations, cancer and cell death. There are various free radical sources, notably ionizing radiation or oxidative stress. In the radiotherapy of cancer and in the case of some anticancer drugs, use is made of cell killing by excessive DNA damage.nbsp; The mechanisms that lead to these products have been studied on the model level and with small double-stranded DNA fragments and are discussed in some detail. The basics of the underlying free-radical chemistry are dealt with in separate chapters. Understanding of the molecular basis of DNA damage and its repair has increased dramatically in recent years, and substantial knowledge now exists concerning the products arising from free-radical attack on DNA. Free-radical DNA damage may lead to mutations, cancer, and cell death. Free radicals have various sources, notably ionizing radiation and oxidative stress. In radiotherapy for cancer and with some anticancer drugs, use is made of cell death by excessive DNA damage. The mechanisms leading to products of free-radical attack which have been studied in models and with small double-stranded DNA fragments are discussed in detail, and the basics of the underlying free-radical chemistry are dealt with in separate chapters.

General

Imprint:	Springer-Verlag
Country of origin:	Germany
Release date:	December 2005
First published:	2006
Authors:	Clemens Sonntag
Dimensions:	235 x 155 x 30mm (L x W x T)
Format:	Hardcover
Pages:	523
Edition:	2006 ed.
ISBN-13:	978-3-540-26120-9
Categories:	Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Genetics (non-medical) > DNA
LSN:	3-540-26120-6
Barcode:	9783540261209

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