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Pharmacology of Immunotherapeutic Drugs (Hardcover, 1st ed. 2020)
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Pharmacology of Immunotherapeutic Drugs (Hardcover, 1st ed. 2020)
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Medicine has entered a golden age in which therapeutic agents are
becoming widely available due to advances in basic science and
technology. As such, many drugs have been developed that target
inflammatory processes and/or the immune system. This book is
intended for health professionals examining the modulation of
inflammation by immunotherapeutic drugs. The immune system fills
the primordial role of host defense and resistance to infections
with pathogenic microorganisms. Several hematopoietic-derived cells
constituting the innate and adaptive immune systems cooperate to
provide barriers for microbial colonization and/or promote pathogen
destruction within the host. Conversely, many immune cells are also
involved in the pathogenesis and propagation of chronic
inflammatory diseases. The beginning of this book details various
components of the immune system including the cell types, lymphoid
tissues, soluble cytokines and surface molecules that are essential
for host defense. Breakdowns in immune tolerance, or dysregulated
immune responses to antigens derived from self tissues or innocuous
sources, can lead to the development of autoimmunity or chronic
inflammatory diseases. Pathophysiologic roles for the immune system
are detailed in corresponding chapters on autoimmunity, epithelial
surfaces (lungs, skin, intestine), and transplantation, with
special emphasis placed on immunotherapeutic drug targets. The last
section of the book focuses on treatments that stimulate our immune
system to specifically target and fight infectious diseases and
cancer. In each chapter, the medications used to treat various
diseases/conditions in terms of their mechanism of action and other
pharmacologic properties are detailed. Chapters begin with a table
showing drug names and classifications. The importance of basic
science and clinical trials cannot be understated in the context of
drug development. As such, the discovery of certain medications
that had a lasting impact in medicine and pharmacy are highlighted
in chapter subsections named "Bench to Bedside." Several clinical
applications of immunotherapeutic drugs are described within end-of
-chapter case studies including practice questions. The
Pharmacology of Immunotherapeutic Drugs is a reference for
immunologists and clinicians (medical doctors, pharmacists, nurses)
examining the modulation of inflammatory processes by a variety of
medications targeting the cells and mediators of our immune system.
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