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Advancing Prion Science - Guidance for the National Prion Research Program (Paperback, New)
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Advancing Prion Science - Guidance for the National Prion Research Program (Paperback, New)
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In Advancing Prion Science, the Institute of Medicinea (TM)s
Committee on Transmissible Spongiform Encephalopathies Assessment
of Relevant Science recommends priorities for research and
investment to the Department of Defensea (TM)s National Prion
Research Program (NPRP). Transmissible spongiform encephalopathies
(TSEs), also called prion diseases, are invariably fatal
neurodegenerative infectious diseases that include bovine
spongiform encephalopathy (commonly called mad cow disease),
chronic wasting disease, scrapie, and Creutzfeldt-Jakob disease. To
develop antemortem diagnostics or therapies for TSEs, the committee
concludes that NPRP should invest in basic research specifically to
elucidate the structural features of prions, the molecular
mechanisms of prion replication, the mechanisms of TSE
pathogenesis, and the physiological function of prionsa (TM) normal
cellular isoform. Advancing Prion Science provides the first
comprehensive reference on present knowledge about all aspects of
TSEsa "from basic science to the U.S. research infrastructure, from
diagnostics to surveillance, and from prevention to treatment.
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