A critical review of the classic, as wells as most recent-and quite
seminal-findings concerning the phenotypic and molecular
characteristics of both fetal and neonatal B and T cells, the cells
that mediate antibody and cellular immune responses in newborns and
infants. Dr. Bona shows how the antibody response of neonates is
modulated by maternal antibodies and how, in certain cases, this
can cause transient or life-threatening neonatal autoimmune
disease. He also describes the characteristics of neonatal
tolerance induced by foreign allo- and self-antigens, which are the
basis for understanding impaired infant immune response and which
provide a rationale for the development of efficient neonatal
vaccines. By making clear the characteristics and differences
between the immune system and the immune responses of both newborns
and infants, compared to those of adults, Dr. Bona offers insights
and challenging hypotheses that promise to help overcome the poor
responses of neonates to various antigens.
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