The development of chiral liquid chromatography, facilitating the
straightforward separation of enantiomers, was a significant
advance in chromatography, leading to widespread application in
analytical chemistry. Application in preparative chromatography has
been less rapid, but with the development of single enantiomer
pharmaceuticals its use is increasingly common in chemical
synthesis at laboratory, pilot plant and even full production
scale.
Written for chemists, chemical engineers and analytical
chemists, Preparative Enantioselective Chromatography demonstrates
the considerable utility of the technique in contemporary
discovery, development and production scale chemistry. By briefly
covering basic preparative chromatography then developing the
discussion to cover chiral stationary phases for preparative use,
method development and practical applications, the first part of
this book serves as an ideal introduction to the technology for
laboratory and pilot plant scale application. The more detailed
information presented in the later chapters, on applications in
discovery, process development and large scale or production
environments, including case studies and equipment selection
issues, ensures the book will serve as a sound reference for
experienced separation scientists.
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