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Books > Medicine > Other branches of medicine > Pharmacology
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Nucleosides and Nucleotides as Antitumor and Antiviral Agents (Paperback, 1993 ed.)
Loot Price: R1,540
Discovery Miles 15 400
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Nucleosides and Nucleotides as Antitumor and Antiviral Agents (Paperback, 1993 ed.)
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Due to the worldwide epidemic of acquired immunodeficiency syndrome
(AIDS), the past ten years have witnessed a flurry of activity in
the chemotherapy of viral diseases. Unprecedented scientific
efforts have been made by scientists and clinicians to combat
infections of human immunodeficiency virus (HIY), the causative
agent. Looking back over the past ten years, we have made
remarkable progress toward the treatment of the viral disease:
isolation of HIV only two years after the identification of the
disease, plus major strides in the areas of the molecular biology
and virology of the retrovirus, etc. More remarkably, the discovery
of the chemotherapeutic agent AZT (Retrovir) was made within two
years after the isolation and identification of the virus, followed
by unprecedented drug development efforts to culminate in the FDA
approval of AZT in twenty-three months, which was a record-breaking
time for approval of any drug for a major disease. The last six to
seven years have particularly been an exciting and productive
period for nucleoside chemists. Since the activity of AZI' was
established in 1985, nucleoside chemists have had golden
opportunities to discover additional anti-HIV nucleosipes, which
are hoped to be less toxic and more effective than AZT, and the
opportunity continues. As we all are aware, AZT possesses extremely
potent anti-HIY activity, and no other nucleoside or non nucleoside
has surpassed the potency of AZT in vitro."
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