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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology
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The Chemistry of Antitumour Agents (Paperback, Softcover reprint of the original 1st ed. 1990)
Loot Price: R1,640
Discovery Miles 16 400
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The Chemistry of Antitumour Agents (Paperback, Softcover reprint of the original 1st ed. 1990)
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Walter C. J. ROSS Emeritus Professor, University of London To
paraphrase a statement made by Howard E. Skipper many years ago,
'We cancer chemotherapists have often exploited and overworked our
chemist colleagues and they have been conveniently forgotten at
award giving times'. This book is an attempt to rectify this and
highlight the contribution of the chemist in modifying the
structure of various types of agent to enhance their effectiveness
as inhibitors of the growth of neoplastic tissues. Cancer
chemotherapy is a relatively new discipline, coming later than the
introduction of sulphonamides and antibiotics. Modern anti-cancer
therapy started with the report of the use of a war gas
methyl-di-(2-chloroethyl)amine (HN2) in 1946 for the treatment of
Hodgkin's disease. The recognition that this compound acted as a
bifunctional alkylating agent under physiological conditions led to
the synthesis of a wide range of drugs with similar properties.
Amongst these were chlorambucil, melphalan, busulphan, and
cyclophos phamide which still find use today. Somewhat later, a
range of antibiotics was found to be effective, for example
aminopterin (1948) and 6-mercaptopurine (1958) to treat acute
leukaemias and 5-fluorouracil and 6-azauracil (1957-8) which were
used against a variety of cancers. Since these early days the net
has been cast ever wider and, as well as ingenious modifications of
the compounds mentioned above, anticancer drugs now include growing
classes of compounds ranging from purely synthetic agents to
natural products. Many of these are discussed in the present book."
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