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Pharmacology of the Skin I - Pharmacology of Skin Systems Autocoids in Normal and Inflamed Skin (Paperback, Softcover reprint of the original 1st ed. 1989)
Loot Price: R3,118
Discovery Miles 31 180
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Pharmacology of the Skin I - Pharmacology of Skin Systems Autocoids in Normal and Inflamed Skin (Paperback, Softcover reprint of the original 1st ed. 1989)
Series: Handbook of Experimental Pharmacology, 87 / 1
Expected to ship within 10 - 15 working days
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The recent interest in the pharmacology of the skin and the
treatment of its diseases has come about for two reasons. The first
is a realisation that many aspects of pharmacology can be studied
as easily in human skin, where they may be more relevant to human
physiology and diseases, as in animal models. Examples of this are
the action of various vasoactive agents and the isolation of
mediators of inflammation after UV irradiation and antigen-induced
dermatitis. The second reason is the fortuitous realisation that a
pharmacological approach to the treatment of skin disease need not
always await the full elucidation of etiology and mechanism. For
example, whilst the argument continued unresolved as to whether the
pilo-sebaceous infection which constitutes acne was due to a
blocked duct or to a simple increase in sebum production,
13-cis-retinoic acid was found quite by chance totally to ablate
the disease; again, whilst cyclosporin, fresh from its triumphs in
organ transplantation, has been found able to suppress the rash of
psoriasis, it has resuscitated the debate on etiology. We are
therefore entering a new era in which the pharmacology and clinical
pharmacology of skin are being studied as a fascinating new way of
exploring questions of human physiology and pharmacology as well as
an important step in the development and study of new drugs, use of
which will improve disease control and at the same time help to
define pathological mechanisms.
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