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Pharmacology of the Skin II - Methods, Absorption, Metabolism and Toxicity, Drugs and Diseases (Paperback, Softcover reprint of the original 1st ed. 1989)
Loot Price: R4,699
Discovery Miles 46 990
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Pharmacology of the Skin II - Methods, Absorption, Metabolism and Toxicity, Drugs and Diseases (Paperback, Softcover reprint of the original 1st ed. 1989)
Series: Handbook of Experimental Pharmacology, 87 / 2
Expected to ship within 10 - 15 working days
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The recent interest in the pharmacology of the skin and the
treatment of its diseases has come about for two reasons. The first
is a realisation that many aspects of pharmacology can be studied
as easily in human skin as in animal models, where they may be more
relevant to human physiology and disease. Examples of this are the
action of various vasoactive agents and the isolation of mediators
of inflammation after UV irradiation and antigen-induced
dermatitis. The second reason is the fortuitous realisation that a
pharmacological approach to the treatment of skin disease need not
always await the full elucidation of aetiology and mechanism. For
example, whilst the argument continued un resolved as to whether
the pilo-sebaceous infection which constitutes acne was due to a
blocked duct or to a simple increase in sebum production, 13-cis
retinoic acid, was found quite by chance totally to ablate the
disease; again, whilst cyclosporin, fresh from its triumphs in
organ transplantation, has been found able to suppress the rash of
psoriasis, it has resuscitated the debate on aetiology. We are
therefore entering a new era in which the pharmacology and clinical
pharmacology of skin are being studied as a fascinating new way of
exploring questions of human physiology and pharmacology as well as
for the development and study of new drugs, use of which will
improve disease control and at the same time help to define
pathological mechanisms.
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