This book introduces a discrete optimisation technique in four
applications: classic Traveller Salesperson Problem (TSP),
Multilocus Genetic Mapping, Multilocus Consensus Genetic Mapping,
and Physical Mapping. Each of the four sections contains the
problem formulation, description of the algorithm, and experimental
results. The foregoing problems are solved on the basis of Guided
Evolution Strategy (GES) algorithm. The algorithm was implemented
in MultiPoint package (http://multiqtl.com). The developed
analytical tools were applied in many genome mapping projects.
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