DNA delivery into cells is a rapidly developing area in gene
therapy and biotechnology. Moreover, it is a powerful research tool
to determine gene structure, regulation, and function.
Viral methods of DNA delivery are well-characterized and
efficient, but little is known about the toxicity and
immunogenecity of viral vectors. As a result, non-viral,
transfection methods of DNA delivery are of increasing
interest.
Synthetic DNA Delivery Systems is a comprehensive and current
resource on DNA transfection. The use of histidine-rich peptides
and polypeptides as DNA delivery systems and self-assembled
delivery systems based on cationic lipids and polymers are
discussed. Targeted delivery to organelles, tumor cells and
dendritic cells comprise an important topic.
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