The volume will serve as a primer on tyrosine kinase signaling and
its importance in cancer. The volume will first introduce the
common denominators of small-molecule and antibody-derived
inhibitors, as well as the general phenomenon of resistance. The
volume will then detail resistance to the most commonly used
classes of tyrosine kinase inhibitors, and will focus specific
chapters on resistance to BCR-ABL1, FLT3, angiokinase family
members, and ALK inhibitors.
General
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