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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Genetics (non-medical) > DNA
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Tandem Repeats in Genes, Proteins, and Disease - Methods and Protocols (Hardcover, 2013 ed.)
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Tandem Repeats in Genes, Proteins, and Disease - Methods and Protocols (Hardcover, 2013 ed.)
Series: Methods in Molecular Biology, 1017
Expected to ship within 12 - 17 working days
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The genomes of humans, as well as many other species, are
interspersed with hundreds of thousands of tandem repeats of DNA
sequences. Those tandem repeats located as codons within open
reading frames encode amino acid runs, such as polyglutamine and
polyalanine. Tandem repeats have not only been implicated in
biological evolution, development and function but also in a large
collection of human disorders. In Tandem Repeats in Genes,
Proteins, and Disease: Methods and Protocols, expert researchers in
the field detail many methods covering the analysis of tandem
repeats in DNA, RNA and protein, in healthy and diseased states.
This will include molecular genetics, molecular biology,
biochemistry, proteomics, biophysics, cell biology, and molecular
and cellular approaches to animal models of tandem repeat
disorders. Written in the highly successful Methods in Molecular
Biology (TM) series format, chapters include introductions to their
respective topics, lists of the necessary materials and reagents,
step-by-step, readily reproducible laboratory protocols, and key
tips on troubleshooting and avoiding known pitfalls. Authoratative
and Practical, Tandem Repeats in Genes, Proteins, and Disease:
Methods and Protocols aids scientists in continuing to study the
unique methodological challenges that come from repetitive DNA and
poly-amino acid sequences.
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