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Books > Science & Mathematics > Biology, life sciences > Molecular biology
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Trypanosomes - After the Genome (Hardcover, New)
Loot Price: R3,429
Discovery Miles 34 290
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Trypanosomes - After the Genome (Hardcover, New)
Expected to ship within 12 - 17 working days
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Trypanosomes cause medically and economically severe diseases such
as Sleeping Sickness and Chagas' Disease in humans and Nagana in
cattle. They are also inherently interesting scientifically, being
single-cell eukaryotes under constant, strong diversifying
selection. The publication of the genome sequences of two key
trypanosomes, Trypanosoma brucei and Trypanosoma cruzi, in 2005 has
provided an exciting new resource to improve our understanding of
the molecular and cellular biology of these important parasites and
aid the development of new drugs and vaccines. The genome
sequences, allied with useful genetic tools and easy molecular
manipulation, will consolidate T. brucei as a eukaryotic model
organism. As a model, it has the added advantage that studies in
this area are directly applicable to understanding and prevention
of disease. Research in this area has never been more exciting. In
this book international experts review the contribution of
trypanosome research to our understanding of eukaryote biology.
Chapters are written from a molecular and genomic perspective and
contain speculative models upon which to base future research
efforts. Topics include: The genome of T. brucei, reverse and
forward genetics, genetic exchange between trypanosomes, chromosome
structure and dynamics, DNA replication, recombination and repair,
transcription, post-transcriptional control of gene expression,
cell structure, cell division and cell cycle, intracellular
transport systems, cell surface architecture, antigenic variation,
and comparative genomics of metabolism. The book provides an
important resource summarising our current knowledge of trypanosome
molecular and cellular biology.
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