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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Genetics (non-medical) > DNA
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Stress-Induced Mutagenesis (Paperback, 2013 ed.)
Loot Price: R5,401
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Stress-Induced Mutagenesis (Paperback, 2013 ed.)
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The discovery of stress-induced mutagenesis has changed ideas about
mutation and evolution, and revealed mutagenic programs that differ
from standard spontaneous mutagenesis in rapidly proliferating
cells. The stress-induced mutations occur during growth-limiting
stress, and can include adaptive mutations that allow growth in the
otherwise growth-limiting environment. The stress responses
increase mutagenesis specifically when cells are maladapted to
their environments, i.e. are stressed, potentially accelerating
evolution then. The mutation mechanism also includes temporary
suspension of post-synthesis mismatch repair, resembling
mutagenesis characteristic of some cancers. Stress-induced mutation
mechanisms may provide important models for genome instability
underlying some cancers and genetic diseases, resistance to
chemotherapeutic and antibiotic drugs, pathogenicity of microbes,
and many other important evolutionary processes. This book covers
pathways of stress-induced mutagenesis in all systems. The
principle focus is mammalian systems, but much of what is known of
these pathways comes from non-mammalian systems.
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