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Books > Science & Mathematics > Biology, life sciences > Biochemistry > Proteins
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GPCR Signalling Complexes - Synthesis, Assembly, Trafficking and Specificity (Hardcover, 2012 ed.)
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GPCR Signalling Complexes - Synthesis, Assembly, Trafficking and Specificity (Hardcover, 2012 ed.)
Series: Subcellular Biochemistry, 63
Expected to ship within 10 - 15 working days
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Main Question: G protein coupled receptors are involved in highly
efficient and specific activation of signalling pathways. How do
GPCR signalling complexes get assembled to generate such
specificity? In order to answer this question, we need to
understand how receptors and their signalling partners are
synthesized, folded and quality-controlled in order to generate
functional proteins. Then, we need to understand how each partner
of the signalling complex is selected to join a complex, and what
makes this assembly possible. GPCRs are known to be able to
function as oligomers, what drives the assembly into oligomers and
what will be the effects of such organization on specificity and
efficacy of signal transduction. Once the receptor complexes are
assembled, they need to reach different locations in the cell; what
drives and controls the trafficking of GPCR signalling complexes.
Finally, defects in synthesis, maturation or trafficking can alter
functionality of GPCRs signalling complexes; how can we manipulate
the system to make it function normally again? Pharmacological
chaperones may just be part of the answer to this question.
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