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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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Cytokines and Colony Stimulating Factors - Methods and Protocols (Paperback, Softcover reprint of hardcover 1st ed. 2003)
Loot Price: R2,926
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Cytokines and Colony Stimulating Factors - Methods and Protocols (Paperback, Softcover reprint of hardcover 1st ed. 2003)
Series: Methods in Molecular Biology, 215
Expected to ship within 10 - 15 working days
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The immune system is a complex network in which different cell
types and soluble factors interact to efficiently eliminate various
kinds of microorganisms as well as aberrant cell clones. The roots
of immunologic investigations reach far into the past. In 430 BC,
Thucydides reported that survivors of the plague did not present a
second time with similar symptoms. The first report of a successful
immu- therapy was made by Edward Jenner in 1798 who found a
protective effect of cowpox vaccination against human pox. Since
then, much knowledge has been accumulated; today, investigations of
the molecular mechanisms of immune regulation are of central
research interest. The novel insights into gene polymorphisms and
gene regulation gathered from this work has improved our knowledge
of individual immune reactions and risk factors in overcoming
infections. Strategies to use the immune system for cancer
treatment have been propelled by the discovery of divergent
immunoregulatory cytokines and the introduction of new gene therapy
strategies to modify immune responses. Recently, the discovery of
various dendritic cells has focused attention on these cell types
as central elements of the immune response and to the possibility
of dendritic cell expansion, maturation, and consecutive
stimulation with immuno- active tumor-specific peptides. Similarly,
methods for ex vivo expansion of various stem cell-derived cell
types have led to an improved therapeutic management of various
benign and malignant diseases.
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