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Neural Regulation in the Vertebrate Endocrine System - Neuroendocrine Regulation (Hardcover, 1999 ed.)
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Neural Regulation in the Vertebrate Endocrine System - Neuroendocrine Regulation (Hardcover, 1999 ed.)
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The objective of this book is to provide recent information on
neural regulation in the endocrine system in vertebrates. Classical
studies have revealed that certain neurons synthesize and release
chemical messengers into the vascular system. These neurons are
endocrine devices that link the brain with the endocrine glands and
other target organs. In vertebrates, the hypothalamus is the seat
for chemical coordination and integration of en- vironmental and
hormonal cues to modulate function of the pituitary gland, and
conse- quently, the functions of other endocrine glands. Exciting
information generated during the past few decades has resulted in
profound alterations in the conceptual fabric of endo- crinology.
From the wealth of information that emerged on neuropeptides of the
central nervous system, and on the other connectivities of various
brain centers, its has become clear that several extra-hypothalamic
sites are also involved in regulation of hypophysial hormones. The
brain has assumed a greater importance in the regulation of the
endocrine sys- tem. However, recent studies have revealed varying
degrees of functional autonomy in hy- pophysial hormone secretion,
which may be due to intrapituitary cytokines. Although
gonadotropin-releasing hormone (GnRH) is a key regulator of
gonadotropin secretion, there exists a GnRH receptor diversity in
vertebrates such as the receptor presence in can- cer cells. Recent
studies have demonstrated the multifactorial nature of the
neuroendo- crine factors involved in growth hormone regulation in
fish. On the other hand, in birds, thyrotropin-releasing hormone
plays a major role in growth hormone release.
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