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Morphofunctional Aspects of Tumor Microcirculation (Paperback, 2012 ed.)
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Morphofunctional Aspects of Tumor Microcirculation (Paperback, 2012 ed.)
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Blood vessels of tumors display many structural and functional
abnormalities. Their unusual leakiness, potential for rapid growth
and remodeling, and expression of distinctive surface molecules
mediate the dissemination of tumor cells in the bloodstream and
maintain the tumor microenvironment. Like normal blood vessels,
they consist of endothelial cells, mural cells and their enveloping
basement membrane. Common features, irrespective of their origin,
size and growth pattern, are absent hierarchy, formation of
large-caliber sinusoidal vessels, markedly heterogeneous density,
increased permeability, decreased and abnormal pericyte-endothelial
cell adhesion, irregular basement membrane structure, and the
incorporation of bone-marrow-derived endothelial progenitor cells
in the microvasculature. A number of specific tumor endothelial
markers have been identified, as well as chromosomal abnormalities.
These markers may be used to deliver drugs specifically and
selectively to the tumor microvasculature.
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