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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology
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Vitamin D and Cancer (Hardcover, 2011 Ed.)
Loot Price: R4,559
Discovery Miles 45 590
You Save: R1,362
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Vitamin D and Cancer (Hardcover, 2011 Ed.)
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Total price: R4,579
Discovery Miles: 45 790
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Substantial data indicate the broad importance of vitamin D-based
signaling in normal human physiology and the broad effects of
vitamin D deficiency. Vitamin D may play a role not only in the
control of bone and mineral metabolism, but also appears to be
involved in immune function, cardiovascular health, thrombosis and
vasculogenesis and neuromuscular function. Considerable
epidemiologic data demonstrate that low vitamin D serum levels
occur very commonly in normal adult populations and that vitamin D
deficiency is associated with an enhanced risk of cancer death from
lung, prostate, head & neck, colorectal and other
gastrointestinal cancers. In addition, preclinical data provide
evidence that calcitriol and other active analogues of calcitriol
have anti-proliferative, pro-differentiative, pro-apoptotic and
anti-angiogenic activity in numerous in-vitro and in-vivo models.
It is quite clear that, while it requires high exposure to
calcitriol to induce these effects, such exposure can be readily
achieved when high dose intermittent therapy is given.
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