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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Neurosciences
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Ionic and Volume Changes in the Microenvironment of Nerve and Receptor Cells (Paperback, Softcover reprint of the original 1st ed. 1992)
Loot Price: R2,847
Discovery Miles 28 470
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Ionic and Volume Changes in the Microenvironment of Nerve and Receptor Cells (Paperback, Softcover reprint of the original 1st ed. 1992)
Series: Progress in Sensory Physiology, 13
Expected to ship within 10 - 15 working days
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Stability of the internal environment in which neuronal elements
are situated is unquestionably an important prerequisite for the
effective transmission of information in the nervous system. During
the past decade our knowledge on the microenvironment of nerve
cells has expanded. The conception that the microenvironment of
neurones comprises a fluid with a relatively simple and stable
composition is no longer accepted; the microenvironment is now
envisaged as a dynamic structure whose composition, shape, and
volume changes, thereby significantly influencing neuronal function
and the trans mission of information in the nervous system. The
modern conception of the neuronal microenvironment is based on the
results of research over the last 20 years. The extracellular space
(ECS) is comprehended not only as a relatively stable
microenvironment containing neurones and glial cells (Bernard
1878), but also as a channel for communica tion between them. The
close proximity of the neuronal elements in the CNS and the
narrowness of the intercellular spaces provides a basis not only
for interaction between the elements themselves, but also between
the elements and their microenvironment. Substances which can cross
the cell membranes can easily find their way through the
microenvironment to adjacent cellular elements. In this way the
microenvironment can assure non-synaptic com munication between the
relevant neurones. Signalization can be coded by modulation of the
chemical composition of the ECS in the vicinity of the cell
membrane and does not require classic connection by axones,
dendrites, and synapses.
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