Synthetic insecticides has long been involved in causing fetal
diseases to human beings as well as cattle. Importance of
biological control of insect pests is aan environment friendly
approach. With advances in biotechnology, recombinant bacteria and
other organisms are being developed for better control of insect
pests. Bacillus thuringiensis (BT) holds a central place among
biocontrol agents. BT produces parasporal crystal proteins (Cry
toxin) during sporulation phase of its growth. These toxins have
defined spectra of toxicity to the target insects only, without
doing any harm to friend insects. More than 260 Cry toxins have
been reported so far. Of which Cry2 is toxic to lepidopteran as
well as dipteran insects. When enters the insect midgut, the toxin
gets activated by proteases present in the insect midgut, make
holes in the gut, as a result insect loses homeostasis and
eventually die without feeding.
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