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Books > Science & Mathematics > Biology, life sciences > Biochemistry > Proteins
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CtBP Family Proteins (Hardcover, 2007 ed.)
Loot Price: R3,020
Discovery Miles 30 200
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CtBP Family Proteins (Hardcover, 2007 ed.)
Series: Molecular Biology Intelligence Unit
Expected to ship within 10 - 15 working days
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When I received an invitation from Ron Landes (Landes Bioscience)
to edit a book on CtBP family proteins, I was gratified to realize
that the importance of these proteins has reached the level of
deserving a 'separate' book. As the reader can see, there has been
significant advancement in our understanding of the fijnctions of
these proteins in the past ten years since CtBPl was cloned in our
laboratory. Genetic and biochemical studies with Drosophila
provided the critical evidence to show that dCtBP is a
transcriptional CO repressor. Genetic studies with mutant mice have
established that these proteins are essential for animal
development. The CtBP family proteins are unique in several
aspects. They were the first among proteins containing a metabolic
enzyme fold to be implicated in transcriptional regulation. The
vertebrate CtBPs exhibit distinct nuclear and cytosolic activities.
The crystal struaures of CtBPl and molecular modeling studies have
illuminated the mo- lecular basis of its dual activity and the
interaction with target peptides. The organization of the
vertebrate CtBP2 gene has provided a novel example of genomic
consolidation indicating how a single gene could code for two di-
verse proteins. I believe that this book will be a valuable
reference source for new researchers to understand more about the
CtBP family proteins and their role in growth, development and
oncogenesis.
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