As the drug discovery process shifts more and more toward
specifically targeting pathways and molecules, model systems
continue to increase in importance, and the mouse, with its
versatility, ease of use, and remarkable similarity to the human
genome, has clearly risen to the forefront of animal model studies.
In Mouse Models for Drug Discovery: Methods and Protocols, experts
in the field present some background for those less familiar with
mice as experimental model platforms as well as a collection of
techniques involving general methods as well as specific disease
topics such as type 1 and 2 diabetes, cardiovascular disease,
arthritis, skin disorders, cancer, the use of behavioral models for
depression and anxiety, neurodegenerative diseases, neuromuscular
diseases, and infectious diseases. Written in the highly successful
Methods in Molecular Biology series format, chapters include
introductions to their respective topics, lists of the necessary
materials and reagents, step-by-step, readily reproducible
laboratory protocols, and notes on troubleshooting and avoiding
known pitfalls.
Authoritative and easy-to-use, Mouse Models for Drug Discovery:
Methods and Protocols will stimulate those not familiar with the
power of the mouse and its potential for the drug discovery
process, and it will encourage the development of new models and
new ways to utilize existing models in order to further the use of
this dynamic animal in this vital field."
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