The Greek word apoptosis was used first by Hippocrates as a
synonym of dislocations of the bones, structural changes related to
tissue, by Marcus Aurelius in political and social context as
failure and decline. The physician Galen extended the medical
meaning of apoptosis to wound healing and inflammation.
Apoptosis, or cell suicide is an integral part of life cycle of
plants and animals indicated by the loss of 140-190g (50-70
billion) cells each day in the human adult, amounting to the body
weight in one year. The growing interest in apoptosis is indicated
by the number of scientific publications since the 1990s which is
now more than 140,000 and will exceed 160,000 by the end of
2008.
The unique feature of this book is the use of synhronized and
reversibly permeabilized cells allowing to visualize the dynamic
nature of chromatin condensation through transitory chromatin and
chromosomal forms including changes upon genotoxic treatment, which
were not seen earlier. The chromatin condensation process is
illustrated from string (DNA) to rope (chromosomes) in more than
160 figures. The interdisciplinary nature of studies summarized in
the book facilitate the global view of readers interested in the
higher order structure of nucleic acids. The wealth of additional
information will attract a wide population of readers. The natural
audience engaged in DNA research such as genetics, cell biology,
biochemistry, molecular biology will find that it contains
essential material.
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