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Books > Medicine > Clinical & internal medicine > Haematology
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Multiple Myeloma and Related Disorders (Hardcover, 2nd ed)
Loot Price: R8,059
Discovery Miles 80 590
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Multiple Myeloma and Related Disorders (Hardcover, 2nd ed)
Expected to ship within 10 - 15 working days
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During the last decade there has been an enormous increase in
knowledge of multiple myeloma and related disorders, reflected in
the publication of more than 5000 articles on the subject in
scientific journals. Much of this has come about as new
technologies have made it possible to refine studies on chromosomes
and genes and to gain information about gene expression. Microarray
is in its early stage but already there have been pattern
descriptions that may have prognostic implications. The impact of
chromosomal abnormalities is now clearer than before, and the
complicated interaction between the stroma cells, the myeloma
cells, and numerous cytokines and their receptors has been better
explained. Attempts have been made to utilize this new knowledge to
develop targeted therapy and although results are still modest,
improvements have been obtained with thalidomide and analogues, as
well as with proteasome inhibitors. It is therefore highly
appropriate that this new comprehensive reference should appear at
this time. The book covers the whole field of multiple myeloma, and
also related diseases such as Waldemstrom's macroglobulinaemia, and
incorporates both the basic science underlying the diseases and
their clinical management. Each chapter has been written to "stand
alone," allowing the reader to dip into particular subject and find
information quickly without the need to browse through multiple
chapters. In addition to the developments described above, all of
which are considered here, many other approaches to targeted
therapy are reviewed.
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