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High Resolution EPR - Applications to Metalloenzymes and Metals in Medicine (Paperback, 2009 ed.)
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High Resolution EPR - Applications to Metalloenzymes and Metals in Medicine (Paperback, 2009 ed.)
Series: Biological Magnetic Resonance, 28
Expected to ship within 10 - 15 working days
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Metalloproteins comprise approximately 30% of all known proteins,
and are involved in a variety of biologically important processes,
including oxygen transport, biosynthesis, electron transfer,
biodegradation, drug metabolism, proteolysis, and hydrolysis of
amides and esters, environmental sulfur and nitrogen cycles, and
disease mechanisms. EPR spectroscopy has an important role in not
only the geometric structural characterization of the redox
cofactors in metalloproteins but also their electronic structure,
as this is crucial for their reactivity. The advent of x-ray
crystallographic snapshots of the active site redox cofactors in
metalloenzymes in conjunction with high-resolution EPR spectroscopy
has provided detailed structural insights into their catalytic
mechanisms. This volume was conceived in 2005 at the Rocky Mountain
Conference on Analytical Chemistry (EPR Symposium) to highlight the
importance of high-resolution EPR spectroscopy to the structural
(geometric and electronic) characterization of redox active
cofactors in metalloproteins. We have been fortunate to have
enlisted internationally recognized experts in this joint venture
to provide the scientific community with an overview of
high-resolution EPR and its application to metals in biology. This
volume, High-Resolution EPR: Applications to Metalloenzymes and
Metals in Medicine, covers high-resolution EPR methods, iron
proteins, nickel and copper enzymes, and metals in medicine. An
eloquent synopsis of each chapter is provided by John Pilbrow in
the Introduction. A second volume, Metals in Biology: Applications
of High-Resolution EPR to Metalloenzymes, will appear later this
year covering the complement of other metalloproteins. One of the
pioneers in the development of pulsed EPR and its application to
metalloproteins was Arthur Schweiger, whose contribution we include
in this volume. Unfortunately, he passed away suddenly during the
preparation of this volume. The editors and coauthors are extremely
honored to dedicate this volume to the memory of Arthur Schweiger
in recognition of his technical advances and insights into pulsed
EPR and its application to metalloproteins. Arthur was extremely
humble and treated everyone with equal respect. He was a gifted
educator with an ability to explain complex phenomena in terms of
simple intuitive pictures, had a delightful personality, and
continues to be sadly missed by the community. It is an honor for
the editors to facilitate the dissemination of these excellent
contributions to the scientific community. Suggestions for future
volumes are always appreciated.
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