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Bone Marrow Transplantation and Other Treatment after Radiation Injury - A review prepared for the Commission of the European Communities, Directorate-General Research, Science and Education (Biology-Medical Research) (Paperback, Softcover reprint of the original 1st ed. 1977)
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Bone Marrow Transplantation and Other Treatment after Radiation Injury - A review prepared for the Commission of the European Communities, Directorate-General Research, Science and Education (Biology-Medical Research) (Paperback, Softcover reprint of the original 1st ed. 1977)
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Acute radiation injury in man has been amply reviewed in the past
decades (1-8). Information for those reviews was mainly derived
from the Hiroshima and Nagasaki experience (3), from radiation
accidents as a con sequence of testing nuclear weapons and the
application of nuclear energy (9-13) and from the intentional
irradiation of patients, mostly for the treatment of malignancies
and/or as conditioning for transplantation (14-20). Further, a
large body of data derived from animal experimentation has led to
cautious extrapolations to the human situation (14). An elaborate
review dealing with early somatic effects of radiation in a man was
published by UNSCEAR ) in 1962 (2). It was supplemented in 1969
with a similar document dealing mostly with radiation-induced
chromosome aberra tions, the effects of radiation on the nervous
system and, radio-active contamination of the environment by
nuclear testing (21). In a more recent UNSCEAR report (1972) the
main topics were genetic effects, carcinogenesis and effects of
radiation on the immune response (22). The early effects of
radiation in man were also expertly and comprehensively reviewed in
a report by the United States National Research Council in 1967
(23).
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