Immunochemistry, recently rechristened molecular immunology, has
been pre occupied throughout its long history with the structure
and function of antibodies and the specificity of antibody-antigen
reactions. With the recent X-ray diffrac of several crystallized
immunoglobulin (Ig) fragments and a whole tion analyses Ig
molecule, the three-dimensional structure of antibodies and their
ligand combining sites has been realized, marking the concluding
stages of a phase of immunological research that can be traced back
at least 75 years. At the same time chemically minded immunologists
have been moving in new directions. A substantial beginning in one
direction has been made with the purification of messenger RNAs
(mRNAs) for Ig chains. Hybridization of these RNAs (or their DNA
copies made with the enzyme reverse transcriptase) to cell DNA is
beginning to provide convincing estimates of the number of
germ-line Ig genes. And some hybridization studies have already
yielded suggestive evidence for translocation of V and C genes from
separate to contiguous positions in DNA isolated from cells at
different stages of differentiation. Moreover, in vitro trans
lation of Ig mRNAs has revealed a remarkably hydrophobic stretch of
about 20 amino acids at the N-terminus of the nascent Ig chain.
This extra piece is absent in the Ig extracted from or secreted by
plasma cells, presumably because it is rapidly cleaved from the
"preimmunoglobulin" chain within the cell, but the extra piece
probably plays a key role in directing the synthesis of prelg to
the cell's secretory pathway."
General
Is the information for this product incomplete, wrong or inappropriate?
Let us know about it.
Does this product have an incorrect or missing image?
Send us a new image.
Is this product missing categories?
Add more categories.
Review This Product
No reviews yet - be the first to create one!
Welcome to Loot.co.za!
Sign in / Register |Wishlists & Gift Vouchers |Help | Advanced search
