Blood Viscosity and Shock - The Role of Hemodilution, Hemoconcentration and Defibrination (Paperback, Softcover reprint of the original 1st ed. 1984)

The hemodynamic significance of the flow properties of blood was put into perspective only during the past decade. Advances in modern technologies today allow the quantitative analy- sis of the fluidity of blood and its components under conditions approximating the flow in vivo, particularly those in the microcirculation. The hematocrit is the most important of the determinants of blood fluidity (reciprocal value of blood viscosity); acute increases in the hematocrit exert deleterious effects on circulation and oxygen transport owing to impaired fluidity of blood. High viscosity of plasma due to hyper- or dysproteinemias initiates the microcirculatory dysfunctions in hyperviscosity syndromes. Furthermore, the fluidity or deformability of red cells might be critically diminished and therefore cause redistribution of blood elements and adversely affect the resistance to flow within the microvessels. In low- flow states blood fluidity most likely becomes the key determinant for microvessel perfu- sion, overriding the neural and local metabolic control mechanisms operative at physiological conditions to adjust blood supply to tissue demand. Microcirculatory disturbances are there- fore encountered whenever driving pressures are reduced, as in shock or hypotension, and distal to stenoses of macrovessels, but also in hemoconcentration due to plasma volume con- traction, polycythemia, leukemia, and dysproteinemia. Based on experimental studies exploring the possibilities and limitations, with regard to improving the fluidity of blood by reducing the hematocrit, the concept of intentional hemo- dilution has been introduced to clinical medicine.

General

Imprint:	Springer-Verlag
Country of origin:	Germany
Series:	Anaesthesiologie und Intensivmedizin Anaesthesiology and Intensive Care Medicine, 160
Release date:	April 1984
First published:	1984
Authors:	H Goslinga
Dimensions:	244 x 170 x 12mm (L x W x T)
Format:	Paperback
Pages:	196
Edition:	Softcover reprint of the original 1st ed. 1984
ISBN-13:	978-3-540-12620-1
Categories:	Books > Medicine > Clinical & internal medicine > Haematology Books > Medicine > Other branches of medicine > Anaesthetics > General Books > Medicine > Other branches of medicine > Accident & emergency medicine > Intensive care medicine Promotions
LSN:	3-540-12620-1
Barcode:	9783540126201

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