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Books > Professional & Technical > Biochemical engineering
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Catalytically Active Nucleic Acids (Paperback, 1st ed. 2020)
Loot Price: R7,300
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Catalytically Active Nucleic Acids (Paperback, 1st ed. 2020)
Series: Advances in Biochemical Engineering/Biotechnology, 170
Expected to ship within 10 - 15 working days
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This volume reviews numerous reaction mechanisms and applications
of nucleic acids with catalytic activity. Written by an
interdisciplinary team of authors, it provides an essential
overview of these acids' fundamental aspects, while also addressing
associated methodologies such as nucleic acid enzyme engineering,
peroxidase-mimicking DNAzymes and Aptazymes. After the discovery of
natural ribozymes - RNA molecules that mediate the cleavage and
formation of phosphodiester bonds and the formation of peptide
bonds - numerous artificial ribozymes with altered catalytic
activities were produced by in vitro and in vivo selection. Unlike
ribozymes, DNAzymes do not occur in nature. Although the catalytic
activity of nucleic acid enzymes is usually much slower than that
of proteins, nucleic acid enzymes with comparable catalytic
activity have been obtained using stringent selection processes.
The key advantages of these enzymes: they are e.g. smaller, easier
to produce and purify than proteins, and can withstand
denaturation, e.g. by heat. Over the last few years, the number of
publications on the applications of enzymatic nucleic acids has
grown steadily. Summarizing the fundamentals and applications of
these acids, this book will not only be an excellent resource for
experts in the field but will also guide young researchers just
starting out in this significant area.
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