mRNA METABOLISM & POST-TRANSCRIPTIONAL GENE REGULATION
Edited by Joe B. Harford and David R. Morris
Gene expression is a process that begins with the transcription of
DNA to an RNA messenger (mRNA), which is then translated into a
protein. Historically, attention has been focused on the regulation
of RNA synthesis (transcription); however, there is a growing
recognition of and appreciation for the importance of the many
regulatory mechanisms that take place after RNA synthesis has been
completed.
mRNA Metabolism and Post-Transcriptional Gene Regulation is the
first comprehensive overview of the various modes of gene
regulation that exist post-transcriptionally. Collecting studies by
some of the top researchers in the field, this volume provides both
an up-to-date review of the complex "life" of an mRNA molecule and
an introduction to current work on the diversity of mechanisms of
post-transcriptional reactions.
Topics covered include:
* RNA structure
* Mammalian RNA editing
* RNA export from the nucleus
* The fundamentals of translation initiation
* Control of mRNA decay in plants
* mRNA metabolism and cancer
* Control of mRNA stability during herpes simplex virus infection
* Regulation of mRNA expression in HIV-1 and other complex
retroviruses
* Nucleases
* RNA localization
A timely contribution to the understanding of genetic regulatory
mechanisms, mRNA Metabolism and Post-Transcriptional Gene
Regulation provides a basis from which potential therapeutic
strategies may be developed. This book will be of vital interest to
cell and molecular biologists at all levels, from graduate students
to senior investigators, clinical researchers, and professionals in
the pharmaceutical and biotechnology industries.
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