Phenotypic Switching: Implications in Biology and Medicine provides
a comprehensive examination of phenotypic switching across
biological systems, including underlying mechanisms, evolutionary
significance, and its role in biomedical science. Contributions
from international leaders discuss conceptual and theoretical
aspects of phenotypic plasticity, its influence over biological
development, differentiation, biodiversity, and potential
applications in cancer therapy, regenerative medicine and stem cell
therapy, among other treatments. Chapters discuss fundamental
mechanisms of phenotypic switching, including transition states,
cell fate decisions, epigenetic factors, stochasticity,
protein-based inheritance, specific areas of human development and
disease relevance, phenotypic plasticity in melanoma, prostate
cancer, breast cancer, non-genetic heterogeneity in cancer,
hepatitis C, and more. This book is essential for active
researchers, basic and translational scientists, clinicians,
postgraduates and students in genetics, human genomics, pathology,
bioinformatics, developmental biology, evolutionary biology and
adaptive opportunities in yeast.
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