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Histophysiology of the Obesity-Diabetes Syndrome in Sand Rats (Paperback)
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Histophysiology of the Obesity-Diabetes Syndrome in Sand Rats (Paperback)
Series: Advances in Anatomy, Embryology and Cell Biology, 130
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1. 1 Experimental Diabetes in the Sand Rat 1. 1. 1 Zoology
Experimental diabetes has been used in numerous animals, of which
rodents have been predominant because of their ease of maintenance
and handling (Herberg 1979), but some species of ape and monkey
have also occasionally been used (Brunk 1971; Malaisse and
Malaisse-Lagae 1970). Herberg et al. (1976) divided rodent species
into two groups based on the similarity of their metabolic response
to the induction of diabetes to the onset of diabetes mellitus in
man. In one of these groups (mouse, Mongolian gerbil, Tuco tuca),
the response of the metabolism to the induction of diabetes was
similar to the changes seen in the onset of adult-type diabetes
mellitus in man; while the other group, which included the sand
rat, spiny mouse, Chinese hamster, and Djungarian hamster,
responded to diabetes induction in a way suggestive of juvenile
insulin-dependent diabetes. Such a subdivision is not without prob
lems, however, particularly since difference occur not only between
the various species of a group (Herberg et al. 1976), but, in our
experience, also between animals of the same species (for instance
the sand rat). Hence, the zoology of animals used for experimental
purposes must also be taken into account. 1 The sand rat is
classified as follows: Species: obesus Genus: Psammomys Subfamily:
Gerbillinae Family: Cricetidae Suborder: Myomorpha Order: Rodentia
Subclass: Placentalia Class: Mammalia Subphylum: Vertebrata Phylum:
Chordata Psammomys obesus was first described by the zoologist P.
J."
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